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KMID : 1132720040020020061
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Genomics & Informatics
2004 Volume.2 No. 2 p.61 ~ p.66
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ChimerDB - Database of Chimeric Sequences in the GenBank
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Kim Nam-Shin
Shin Seok-Min
Cho Kwang-Hwi
Lee Sang-Hyuk
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Abstract
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Fusion proteins resulting from chimeric sequences are excellent targets for therapeutic drug development. We developed a database of chimeric sequences by examining the genomic alignment of mRNA and EST sequences in the GenBank. We identified 688 chimeric mRNA and 20,998 chimeric EST sequences. Including EST sequences greatly expands the scope of chimeric sequences even though it inevitably accompanies many artifacts. Chimeric sequences are clustered according to the ECgene ID so that the user can easily find chimeric sequences related to a specific gene. Alignments of chimeric sequences are displayed as custom tracks in the UCSC genome browser. ChimerDB, available at http://genome.ewha.ac.kr/ECgene/ChimerDB/, should be a valuable resource for finding drug targets to treat cancers.
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KEYWORD
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chimeric sequence, chromosomal translocation, trans-splicing, multi-locus transcription
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